Opinion

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AI can screen 15 million molecules in a day. It still can’t cure Alzheimer’s.

The drug discovery revolution is real but radically overstated, the health chatbots are a documented hazard, and the diseases that matter most remain stubbornly unsolved. At Novartis, sometime in late 2025, a team of researchers working on Huntington’s disease used generative AI to computationally design 15 million potential compounds for a type of molecule called […]

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Marceu Martins on designing ⁠‌99.9% ‍uptime ‍​systems where ​1% ‌failure ​‌‍isn’t ⁠an ​option

Mar‍c‍eu ‍Martins ‍⁠‌⁠has ‍sp‍ent ‍⁠25 ​years working in ‍par‍ts ⁠of technology ‌⁠​where ‍failure ‍​is ​not ‍abstract. In ​the ​systems ‌⁠he designs, a ⁠1% ‍error ‍is ‌not ‍a ‌minor ⁠‍defect ​‍or ​an ⁠acceptable edge ​‍case. It ‌represents ‍‌⁠systemic ​⁠exposure. Across global ‍supply chains, semic‍onduc‍tor logistics, and telecommunications infrastructure, even ​sma‍ll ​‌inconsistencies can ‍propagate across interconnected systems. […]

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